From: Ashtma-Chronic obstructive pulmonary disease overlap syndrome (ACOS): current evidence and future research directions
Major criteria
Minor criteria
Increase in FEV(1) ≥ 15% and ≥ 400 ml
High total IgE >100 UI/ml
Eosinophilia in sputum > 5%
Personal history of atopy
Personal history of asthma
Increase in FEV(1) ≥ 12% and ≥ 200 ml on 2 or more occasions