Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Table 5 Coefficients of correlation values between erythrocyte anti-oxidation enzyme activities with FEV₁ (% predicted) in COPD patients according to GOLD stage classification

GOLD stage classification of COPD
Study parameters	GOLD stage II coefficient (r)	GOLD stage III coefficient (r)	GOLD stage IV coefficient (r)
Superoxide dismutase (U/mg protein)	0.20	0.00	-0.21
Catalase (U/mg protein)	-0.09	-0.21	0.00
Glutathione s transferase (U/mg protein)	-0.73**	0.09	0.10
Glutathione peroxidase (U/mg protein)	0.24	0.02	-0.11
Glutathione reductase (U/mg protein)	-0.47*	-0.31*	-0.24^¥
Total antioxidant status (μM Fe²⁺/l)	-0.07	-0.38*	0.20

Significance of correlation between erythrocyte antioxidant enzymes activities with FEV₁ (% predicted) according to GOLD stages:^¥
p < 0.07, Border line significance, *p < 0.05; **p < 0.001, ‘r’ denotes Pearson correlation coefficient

ISSN: 2054-9040