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Table 1 FEV1 associated SNPs identified using GWAS meta-analyses

From: Developmental genetics of the COPD lung

Gene Locus SNP Measure Reference
ST3GAL3 1p34.1 rs121374475 FEV1 decline Tang et al. 2014 [28]
NFIA 1p31.3 rs766488 FEV1 decline Tang et al. 2014 [28]
ESRRG/GPATCH2 1q41 rs17698444 FEV1 decline Tang et al. 2014 [28]
BAZ2B 2q24.2 rs12692550 FEV1 decline and bRate of FEV1 change Tang et al. 2014 [28]
FOSL2/PLB1 2p23.2 rs10209501 bRate of FEV1 change Tang et al. 2014 [28]
TNS1 2q35 rs2571445 FEV1 Repapi et al. 2010 [19]
HDAC4 2q37.3 rs12477314 FEV1 Soler-Artigas et al. 2011 [36]
MECOM 3q26.2 rs1344555 FEV1 Soler-Artigas et al. 2011 [36]
FLJ25363/MIR4445 3q13.13 rs1729588 bRate of FEV1 change Tang et al. 2014 [28]
GSTCD 4q24 rs10516526 FEV1 Repapi et al. 2010 [19]
FLJ20184 4q24 46 SNPs across locus FEV1 Hancock et al. 2010 [20]
INTS12 4q24 46 SNPs across locus FEV1 Hancock et al. 2010 [20]
GSTCD 4q24 46 SNPs across locus FEV1 Hancock et al. 2010 [20]
NPNT 4q24 46 SNPs across locus FEV1 Hancock et al. 2010 [20]
HHIP 4q31 rs12604628 FEV1 Repapi et al. 2010 [19]
PDE4D a 5q12 rs298028 FEV1 Obeidat et al. 2011 [22]
HTR4 5q33 rs3995090 FEV1 Repapi et al. 2010 [19]
ZKSCAN3 6p22.1 rs6903823 FEV1 Soler-Artigas et al. 2011 [23]
MTHFD1L a 6q25.1 rs803450 FEV1 Obeidat et al. 2011 [22]
NAT2 a 8p22 rs6988857 FEV1 Obeidat et al. 2011 [22]
CDC123 10p13 rs7068966 FEV1 Soler-Artigas et al. 2011 [23]
C10orf112/MALRD1 10p12.31 rs10764053 bRate of FEV1 change Tang et al. 2014 [28]
C10orf11 10q22.3 rs11001819 FEV1 Soler-Artigas et al. 2011 [23]
ME3 11q14.2 rs507211 bRate of FEV1 change Tang et al. 2014 [28]
CNTN5 a 11q22 - q22.2 rs17133553 FEV1 Obeidat et al. 2011 [22]
TRPV4 a 12q24.1 rs3742030 FEV1 Obeidat et al. 2011 [22]
TMCO3 13q34 rs2260722 FEV1 decline Tang et al. 2014 [28]
SERPINA1 a 14q32.13 rs3748312 FEV1 Obeidat et al. 2011 [22]
IL16/STARD5/TMC3 a 15q25.1 rs4077833 FEV1 decline Tang et al. 2014 [28]
SV2B 15q26.1 rs8027498 FEV1 decline Tang et al. 2014 [28]
MYH11 16p13.11 rs8051319 FEV1 decline Tang et al. 2014 [28]
CACNG4 17q24.2 rs740557 FEV1 decline Tang et al. 2014 [28]
KCNJ2/SOX9 17q24.3 rs11654749 FEV1 Hancock et al. 2012 [24]
BCL2 a 18q21.3 rs2850760 FEV1 Obeidat et al. 2011 [22]
MACROD2 a 20p12.1 rs204652 FEV1 Obeidat et al. 2011 [22]
  1. Top hits for FEV1 association seen in 6 studies of genome-wide association study meta-analyses [19, 20, 22–24, 28]
  2. aTop hits that were outside the level of significance, bIn meta-analyses of 5 cohorts with over 3 measurements per participant
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COPD Research and Practice

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