Skip to main content

Table 1 Asthma-COPD overlap syndrome, definitions and diagnostic criteria

From: The asthma-COPD overlap syndrome: a new entity?

Gibson P, Simpson J [7], 2009 Asthma and COPD (symptoms of increased variability of airflow and incompletely reversible airflow obstruction)
COPD gene [5],2011 Patients with COPD and a diagnosis of asthma before the age of 40
Spanish consensus [11], 2012 (patients must fulfill 2 major criteria or 1 major and 2 minor) Major criteria
Very positive bronchodilator response (>400 ml and >15 % in FEV1)
Sputum eosinophilia
Previous diagnosis of asthma
Minor criteria
Increased total serum IgE
Previous history of atopy
Positive bronchodilator test (>200 mL and >12 % in FEV1) on at least two occasions
Czech Republic guidelines [13], 2013 (patients must fulfill 2 major criteria or 1 major and 2 minor) Major criteria
Strong bronchodilator test positivity (FEV1 > 15 % and > 400 ml)
Positive bronchial challenge test
FeNO > 45–50 ppb and/or sputum eosinophilia ≥3 %
Histoy of asthma
Minor criteria
Mild bronchodilator test positivity (FEV1 > 12 % and > 200 ml)
Increased total IgE
History of atopy
Louie S et al. [8], 2013 -Asthma with partially reversible airflow obstruction with/without emphysema or reduction of DLCO <80 % predicted.
-COPD with emphysema accompanied by reversible or partially reversible airflow obstruction, with or without environmental allergies or reduced DLCO
Menezes M et al. [30], 2013 FEV1/FVC <0.7 and medical diagnosis of asthma or wheezing + positive bronchodilator test (>200 mL and >12 % in FEV1)
Izquierdo-Alonso et al. [9] (2013) COPD (more than 10 pack-years and post bronchodilator FEV1/FVC < 0.7)
History of asthma before the age of 40
Normal carbon monoxide (CO) diffusion capacity and absence of pulmonary emphysema demonstrated by imaging techniques
GOLD-GINA document [15] (2014) Persistent airflow limitation with several features usually associated with asthma and several features usually associated with COPD
Finish guidelines [14] (2014) (patients must fulfill 2 main criteria or 1 main and 2 additional) Main criteria
Significant bronchodilatory effect (FEV1 > 15 % and > 400 ml)
Sputum eosinophilia or elevated ENO (>50 ppb)
Previous asthma symptoms (starting before the age of 40)
Additional criteria
Elevated total IgE
Atopy
Repeated significant bronchodilatory response (FEV1 > 12 % and >200 ml)
PEF-follow up typical of asthma