COPD Group
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Control Group
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All Groups
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Former smoker
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Former smoker
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Active smoking
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≥10 pack year smoking history, quit at least 3 months prior to enrollment
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≥10 pack year smoking history, quit at least 3 months prior to enrollment
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Any significant pulmonary disease other than COPD which would limit the interpretability of the pulmonary function measures
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Age 40-85
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Age 40-85
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Moderate or severe COPD:
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Spirometry without evidence of airflow obstruction
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COPD exacerbationa in the prior six weeks
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FEV1/FVC below the lower limit of normal and FEV1 < 70 % predicted for age and height
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No evidence of emphysema on CT imaging, if previously obtained
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Currently taking ≥10 mg a day of prednisone or equivalent systemic corticosteroid
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Inability to perform exhaled breath condensate, spirometry, or complete respiratory symptom questionnaire
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Pregnant or intending to become pregnant
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